Yoko Okouchi (Rena Tanaka) is a beautiful and bright surgeon. She is kind to her patients, but she also has a dark side. She lacks a sense of guilt and also pity for others. One day, aspiring writer Masato Nanba feels severe pain in his abdomen and goes to the hospital. There, Yoko Okouchi diagnoses Masato with appendicitis and treats him well. After his successful surgery, Masato stays at the hospital as a patient. He is happy that Yoko Okouchi is his doctor, but that will soon change.
Kenichi Endo, Ren Osugi, Tomorowo Taguchi, Susumu Terajima, Yutaka Matsushige and Ken Mitsuishi all receive offers to take part in a big budget drama series with a famous lead actor and world famous director. To study their roles and relationships, the director asks the six supporting actors to live together for 3 months at a share house. The actors begin their temporary living arrangement. An incident from 10 years ago though causes the actors to hold resentment.
Hanabi Yasuraoka (Miyu Yoshimoto) and Mugi Awaya (Dori Sakurada) look an ideal high school couple, but, they both like someone else. Hanabi Yasuraoka has liked Narumi Kanai (Kouki Mizuta) since she was a kid and Mugi Awaya likes his private tutor Akane Minagawa (Rina Aizawa).
As a couple, Hanabi Yasuraoka and Mugi Awayai have 3 conditions: they are not supposed to like each other, they will break up if either of them succeed in love with their secret crush and they will fulfill their physical desires.
Ranko Ando (Karina) is a detective. She is 32-years-old and single. Ranko Ando does her job well and has solved difficult cases. She doesn't listen to others and doesn't care what others think about her. She works with detective Toshio Aoyama (Shigeaki Kato). He holds a strong sense of justice and cares what others think about him.
Entertainers Bakarhythm and Wakabayashi Masayasu live on the same floor of an apartment building in Tokyo. One day, the two of them discover that Nikaido Fumi lives in this building. She joins their group before they even realize it and the trio become close friends who solve one another’s worries and problems.
During the Sengoku period, the Ii family governs the Totomi region. Due to many past wars, there are no more male successors left to become a lord. Naotora Ii (Kou Shibasaki), the only daughter of the lord, now becomes a lord. She faces a difficult period. The constant love from her fiance, whom she became engaged with at a young age, helps her to keep moving forward.