In the late Tokugawa Shogunate, Asa was born as the second daughter of a wealthy merchant in Kyoto, Japan. Later, in Osaka, Asa entered various business fields like coal mines, banks, life insurance. She also founded the first female university in Japan.
In 1930 and as a young child, Tsuneko Kohashi lives at Enshu in Shizuoka Prefecture. She has a happy life with her parents and two younger sisters. Things change after her father dies from tuberculosis. Her father asked Tsuneko Kohashi to take care of the family in his place. Due to financial difficulties, her mother Kimiko decides to move the family to Tokyo where Tsuneko's grandmother lives.
In Tokyo, Tsuneko eventually graduates from school. She begins to work at small publishing company and learns editing. By 1945, Tsuneko decides to publish a magazine for women with the help of her two younger sisters. Her sisters do not know anything about the publishing world. A man then appears in front of them. The man is Isaji Hanayama.
Yu Takada (Ryosuke Yamada) works at a company. Since he was a kid, his father has always favored his smarter, older brother. His father doesn't seem to care much about Yu, but Yu craves affection from his father.
One day, Yu meets a woman by chance. That experience wasn't that good, but he begins to have feelings for her. Yu then learns she is his older brother's girlfriend.
Yoichi Haruno (Hiroshi Tamaki) is 35-years-old and works for a company. His wife, Chisato (Kana Kurashina), is 28-years-old. Before they had a child, their marriage life was easygoing. After having their child, their relationship changes. Yoichi feels that Chisato is cold to him, but he doesn't know why.
A postman learns that he doesn't have much time left to live due to a terminal illness. A devil then appears in front of him and offers to extend his life if he picks something in the world that will disappear. The man thinks about his relationships with ex-friends, ex-lovers, relatives and colleagues who will be sincerely sad when he dies.
Hitomi Serizawa (Karina) works at a real estate corporation as a team leader. She is engaged to physician. On the 100th day before the wedding, Hitomi is diagnosed with a brain tumor. Her mother appears even though they have not seen each other for the past 28 years. Her mothers with her bright personality offers Hitomi encouragement and she tries to live positively.
Hisashi Ieji (Takuya Kimura) works for a securities company. 5 years ago, Hisashi Ieji had an accident at the place where he was sent to work. Due to the accident, his recent memories have become blurred. He also doesn't have any feelings for his wife Megumi Ieji (Aya Ueto) or 4-year-old son. To him, its like his wife and son are wearing masks. Hisashi Ieji does have fond memories for his ex-wife and daughter. He divorced his ex-wife 5 years ago. To find out what happened to him for the past 5 years, Hisashi Ieji goes on a trip to find himself and he takes 10 mysterious keys.
A story of a married couple in short dramas, portraying four unforgettable moments in their lives from their encounter to separation. She (Tokiwa Takako) is the celebrated stage actress of a theatre company and he (Kitamura Kazuki) is a mere person in charge of props, who has secretly burned with love for her for some time. On Christmas eve in 1987, he finally gathers the courage to hand her a slip of paper with his contact details written on it. Observing the bewildered expression on her face, he half gives up and boards the train to go home. However, she is visible from the train window. He sees her standing at the platform looking and smiling at the paper he had passed to her earlier. Love soon blossoms and they get married and have children. They overcome differences and as they near the end of their lives, he makes his wife a last present.
Yasutake Shingo works as a newspaper reporter but his life is stiffled and lifeless. That changes one day when he meets the irrepressible Matsunaga Chie by accident. Just as their relationship is blossoming however, Chie tells Shingo that she has breast cancer. Shingo determines to marry Chie right away, but she'll have to go through surgery and cancer treatments first. Then, not long after their marriage, Chie becomes pregnant. But that means she could lapse back into cancer again. Still, the couple decides to have the child, a girl they name Hana. But as the years pass and Chie bounces between the cancer and cures, she decides she had better teach Hana to take care of things in her place, just in case the worst happens.